AN ILLUSTRATIVE RESEARCH TO ASSESS "NDRD" (NON-DIABETIC RENAL DISEASE) FREQUENCY IN THE PATIENTS DIAGNOSED WITH T2DM (TYPE 2 DIABETES MELLITUS)

Objective: In type 2 diabetes patients who encounter renal biopsy for unbalanced kidney functions, to measure the frequency NDRD is the main objective of this research. These unbalanced functions of kidney comprised hematuria, proteinuria in the nephrotic and non-nephrotic range and quality increase kidney failure. Methods: This research held at Allied Hospital, Faisalabad from January 2017 to December 2017 (Department of Pathology). This assessment of kidney surgery was done of 73 patients of type 2 diabetes. These patients were also likely to have kidney disorder except diabetic glomerulosclerosis (DGS). This was due to unidentified hematuria, in nephrotic and non-nephrotic position presence clinically important proteinuria and quickly increasing kidney failure or unidentified kidney failure with usual kidney size. As observed on the light microscope and immunofluorescence investigations, the damaged kidney was reported in three group of patients. The patients in group-1 had just NDRD, in group 2, patients have NDRD along with DGS and patients’ group 3 had only DGS. Using SPSS software, the association of investigation with the detached figure in each group and diabetes timing were measured and estimated. Result: Total 73 patients were included in the study. Out of these 73, males and females were 46 and 27 respectively (1 7:1). During the performance, group 1 and 2 tries to have patients with low ages (49.26 ±9.37 years and 49.0 ±5.27 years respectively) as compared with group 3. (53.62 ±6.62 years). The mean diabetic time period in group 1 was observed 9.9 ±10.42 years in group 2-time duration was 7.5 ±3.38, and in group 3, 13.31 ±1.71. 30 patients (41.1%) out of 73 had only NDRD, 6(8.21%) had NDRD along with DGS while in 37(50.7%), only DGGS was noticed. The abrasions that were very usual include Focal segment glomerulosclerosis (FSGS) and tubulointerstitial nephritis (TIN) and their presence was reported as 22.2% and 19.4% respectively. In NDRD patients of group 1 and 2 (3.064±1.38gms/24hrs and 3.316 ±0.97 gms/24hrs respectively) the quantity of proteinuria was higher, as compared to DGS patients of group 3 (2.815±0.916 gms/24 hrs.). But these values are not important statistically. If we compare serum cretonne in all groups, it was found remarkably higher in group 3 patients (3.391±0.95 mg(di) and group 1 (2.563±0.95 mgdL) and group 2 (2.633±0.952 mg dl) (p=0.0002). In NDRD patients, the hematuria was noticed in higher quantity (32.5% in group 1 and 33.3%) in group 2) as compare to patients of DGS in group 3 But these figures are not imported statistically. Conclusion: The study suggests that in type 2 diabetic patients, a high quantity of NDRD is present. These patients encounter surgery of kidney due to due to the damaged working of the kidney. The study also highlights the importance of surgery in patients experiencing the renal failure so that control disease could be adapted accordingly. Keywords: Type II diabetes, Diabetic glomerulosclerosis, Non-diabetic renal diseases